Population
Single isolated smooth muscle cells of the guinea-pig ileum
Comparison
Whole-cell patch-clamp technique with voltage… vs Control conditions
Design
Preclinical
Authors
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Regenerative CICR in guinea-pig ileal cells does not inform clinical practice; leaves open translation to human GI smooth muscle physiology.
This preclinical study demonstrates that the Ca(2+)-induced Ca2+ release mechanism in guinea-pig ileal smooth muscle cells operates in a regenerative manner with a definite threshold for Ca2+ influx.
Zholos et al. (1992) studied this question.
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