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August 1, 1990The Journal of PhysiologyOpen Access

Characteristics of transient outward currents in single smooth muscle cells from the ureter of the guinea‐pig.

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Population

Single smooth muscle cells isolated from guinea-pig ureter

Design

Preclinical

Authors

YIYuji ImaizumiNagoya City UniversityKMKatsuhiko MurakiGriffith UniversityMWMinoru WatanabeHitotsubashi University

Discussion

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Implication

ITO may regulate guinea-pig ureter excitability; extends smooth-muscle channel mapping but leaves open human relevance.

Structured PICO

P
Population
Single smooth muscle cells isolated from guinea-pig ureter
I
Intervention
Depolarization and pharmacological blockade (1 mM-Cd2+, 2 mM-TEA+, 3 mM-4-aminopyridine)
O
Outcome
Characteristics of transient outward currents (conductance, activation/inactivation kinetics, voltage dependence)surrogate

In guinea-pig ureter smooth muscle cells, an A-type transient outward current (ITO) was identified that may regulate membrane excitability by opposing Ca2+ currents near the action potential threshold.

Cite This Study

Imaizumi et al. (1990) studied this question.

synapsesocial.com/papers/6a741c3bda7582b554eb029fhttps://doi.org/10.1113/jphysiol.1990.sp018173
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outward current in single smooth muscle cells of the guinea pig taenia coli.1989 · 29 citations
  2. 2A voltage‐dependent outward current with fast kinetics in single smooth muscle cells isolated from rabbit portal vein.1989 · 87 citations
  3. 3Cellular calcium regulates outward currents in rabbit intestinal smooth muscle cell1987 · 105 citations
  4. 4Membrane currents recorded from a fragment of rabbit intestinal smooth muscle cell1986 · 86 citations
  5. 5Calcium‐activated potassium channels in single smooth muscle cells of rabbit jejunum and guinea‐pig mesenteric artery.1986 · 303 citations