December 1, 1988The Journal of PhysiologyOpen Access

Asymmetric charge movement and calcium currents in ventricular myocytes of neonatal rat.

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Population

Isolated ventricular cells from neonatal rats

Design

Preclinical

Authors

AFA C FieldAustralian National University CHCaryl E. HillAustralian National University GLGraham D. LambElectrophysiology

Discussion

Member takes

Implication

Suggests DHP sites contribute to cardiac charge movement in neonates; leaves open extension to adult human myocytes.

Structured PICO

Population

Isolated ventricular cells from neonatal rats

Intervention

Whole-cell patch-clamp technique (including application of 10 microM nifedipine and various voltage protocols)

Outcome

Calcium and sodium currents and non-linear capacitive currentssurrogate

In neonatal rat ventricular myocytes, a large part of the charge movement may be related to dihydropyridine binding sites and involved with gating calcium channels, showing similarities to skeletal muscle excitation-contraction coupling.

Cite This Study

Field et al. (1988) studied this question.

synapsesocial.com/papers/6a758025b172e98d88f553fb https://doi.org/10.1113/jphysiol.1988.sp017380

View Full Paper

Ask AI

Bookmark

Asymmetric charge movement and calcium currents in ventricular myocytes of neonatal rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Asymmetric charge movement and calcium currents in ventricular myocytes of neonatal rat.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider