Key result
In guinea-pig ventricular cells, substitution of intracellular K+ with Cs+ eliminated negative slope conductance and shifted the resting potential, while inorganic blockers suppressed inward Ca2+ current.
Population
Single ventricular cells of guinea-pig
Comparison
Voltage clamp and internal dialysis with ion… vs Control conditions
Design
Preclinical
Authors
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Animal data leave open human translation of Ca2+ current properties; hypothesis-generating for ventricular myocyte research.
This basic electrophysiology study demonstrates the isolation of calcium currents in guinea-pig ventricular cells and clarifies that extracellular potassium does not directly inhibit the calcium channel.
Matsuda et al. (1984) studied this question. Ion substitution and channel blockers vs. Control conditions was evaluated on Calcium current and its sensitivity to monovalent cations. In guinea-pig ventricular cells, substitution of intracellular K+ with Cs+ eliminated negative slope conductance and shifted the resting potential, while inorganic blockers suppressed inward Ca2+ current.
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