Population
Guinea-pig ventricular myocytes superfused with Na+,K(+)-free solution
Comparison
Dialysis with non-hydrolysable analogues of GTP vs Dialysis with substrate-free solution, 100…
Design
Preclinical
Authors
Loading...
Animal data indicate direct Gs effects on cardiac ICa; leaves open translation to human physiology or therapy.
Activated Gs proteins have a direct stimulatory effect on cardiac Ca2+ channels, independent of the adenyl cyclase phosphorylation pathway.
Shuba et al. (1990) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: