Population
Cardiac cells (implied by 'cardiac L-type Ca2+ channels')
Comparison
Chronic intracellular application of guanosine… vs Control conditions
Design
Preclinical
Authors
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Warrants caution against clinical translation; extends mechanistic understanding of G-protein regulation of cardiac ICa but remains hypothesis-generating.
Chronically applied GTP gamma S can inhibit activation of cardiac L-type Ca2+ currents by isoprenaline via a PTX-sensitive G-protein and accelerate responses to cAMP-dependent phosphorylation.
Kozlowski et al. (1994) studied this question.
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