Population
Single atrial myocytes obtained by enzyme perfusion from hearts of adult guinea-pigs
Comparison
Functional removal of the sarcoplasmic reticulum… vs Baseline state (before caffeine application)
Design
Preclinical
Authors
Loading...
SR Ca2+ sequestration shapes atrial transients in this guinea-pig model; leaves open relevance to human physiology or therapy.
The sarcoplasmic reticulum in guinea-pig atrial myocytes rapidly sequesters entering calcium, attenuating entry transients and creating a staircase pattern.
Lipp et al. (1992) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: