Key result
In guinea-pig atrial myocytes, cell geometry and varying subcellular Ca2+ release patterns greatly affect the time course of Ca2+-activated membrane currents.
Population
Cultured adult guinea-pig atrial myocytes (citrate-loaded)
Design
Preclinical
Authors
Loading...
Heterogeneous ICa-triggered Ca2+ release in atrial myocytes leaves open uniform SR coupling models; requires intact-tissue and in-vivo validation.
Individual cell geometry and local SR Ca2+ loading are key determinants of subcellular Ca2+ signaling and membrane currents in cardiac myocytes.
Lipp et al. (1996) studied this question. Voltage steps was evaluated on Subcellular Ca2+ signaling and membrane currents. In guinea-pig atrial myocytes, cell geometry and varying subcellular Ca2+ release patterns greatly affect the time course of Ca2+-activated membrane currents.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: