March 1, 1998The Journal of PhysiologyOpen Access

Variability in spontaneous subcellular calcium release in guinea‐pig ileum smooth muscle cells

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Population

Guinea-pig ileum smooth muscle cells (fluo-3-loaded myocytes)

Design

Preclinical

Authors

DGDmitri GordienkoInserm TBT. B. BoltonElectrophysiology MCMark B. CannellElectrophysiology

Discussion

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Implication

Preclinical data in guinea-pig ileum; leaves open any role for ryanodine receptor sparks in human smooth muscle disorders or therapy.

Structured PICO

Population

Guinea-pig ileum smooth muscle cells (fluo-3-loaded myocytes)

Intervention

Application of Cd2+ (200 microM), ryanodine (30 microM), or thapsigargin (0.1 microM)

Outcome

Characteristics and frequency of spontaneous localized transient increases in intracellular calcium (Ca2+ sparks) and Ca2+ wavessurrogate

Spontaneous calcium sparks in guinea-pig ileum smooth muscle cells arise from ryanodine receptors and exhibit wide spatio-temporal variability, likely contributing to calcium wave propagation via calcium-induced calcium release.

Cite This Study

Gordienko et al. (1998) studied this question.

synapsesocial.com/papers/6a8554fefc70cb81dc201d94 https://doi.org/10.1111/j.1469-7793.1998.707bs.x

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Variability in spontaneous subcellular calcium release in guinea‐pig ileum smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Variability in spontaneous subcellular calcium release in guinea‐pig ileum smooth muscle cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider