Key result
High spatial resolution confocal imaging revealed that Ca2+ sparks in rat cardiac myocytes are often comprised of smaller, triggered units of Ca2+ release rather than being indivisible elementary events.
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No immediate clinical implications; leaves open whether sub-spark Ca2+ units influence human myocyte function or arrhythmias.
Parker et al. (1996) studied this question. High spatial resolution confocal imaging was evaluated on Ca2+ spark characteristics (spacing, diffusion, synchrony). High spatial resolution confocal imaging revealed that Ca2+ sparks in rat cardiac myocytes are often comprised of smaller, triggered units of Ca2+ release rather than being indivisible elementary events.
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