Population
Enzymatically dissociated mouse cardiac ventricular cells
Design
Preclinical
Authors
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No immediate clinical implications for arrhythmia management; leaves open multi-channel spark mechanisms in human excitation-contraction coupling.
Calcium sparks in mouse ventricular myocytes exhibit low latency variability and all-or-none behavior, suggesting they are elementary events underlying cardiac excitation-contraction coupling involving multiple SR release channels.
Bridge et al. (1999) studied this question.
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