April 1, 1999The Journal of PhysiologyOpen Access

Relationship between L‐type Ca²⁺ current and unitary sarcoplasmic reticulum Ca²⁺ release events in rat ventricular myocytes

View Full Paper

Ask AI

Bookmark

Population

Single rat ventricular myocytes

Design

Preclinical

Authors

MCMei Lin CollierAllegheny College ATAndrew P. ThomasRutgers, The State University of New Jersey JBJoshua R. BerlinRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Supports single L-type channel spark triggering in animals; leaves open translation to human excitation-contraction coupling.

Structured PICO

Population

Single rat ventricular myocytes

Intervention

Voltage clamp with patch pipettes containing 0.1 microM fluo-3, with or without nifedipine (0.1-8 microM)

Outcome

Time courses of Ca2+ current and Ca2+ spark occurrencesurrogate

The study demonstrates that the time courses of macroscopic Ca2+ current and Ca2+ spark occurrence are closely related, suggesting Ca2+ sparks are initiated by the opening of a single L-type Ca2+ channel.

Cite This Study

Collier et al. (1999) studied this question.

synapsesocial.com/papers/6a76d81af6b553d308ae14cd https://doi.org/10.1111/j.1469-7793.1999.117aa.x

View Full Paper

Ask AI

Bookmark

Relationship between L‐type Ca²⁺ current and unitary sarcoplasmic reticulum Ca²⁺ release events in rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Relationship between L‐type Ca²⁺ current and unitary sarcoplasmic reticulum Ca²⁺ release events in rat ventricular myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider