Key result
Patch depolarization with Ca2+ as the charge carrier significantly increased the local Ca2+ spark rate from 119 to 610 sparks/cell/s (P<.005).
Population
Single rat cardiac ventricular cells
Comparison
Patch depolarization with Ca2+ as the charge… vs Patch depolarization with Ba2+ in the pipette…
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for local Ca2+ release mechanisms in rodent myocytes and leaves open human translation.
Absolute Event Rate: 610% vs 119%
p-value: p=<.005
Voltage-activated Ca2+ entry through L-type Ca2+ channels triggers the release of Ca2+ from the sarcoplasmic reticulum in direct proximity to those channels in rat ventricular cells.
Shorofsky et al. (1998) studied None (single rat cardiac ventricular cells). Patch depolarization with Ca2+ as charge carrier vs. Basal state / Ba2+ in pipette solution was evaluated on Ca2+ spark rate (p=<.005). Patch depolarization with Ca2+ as the charge carrier significantly increased the local Ca2+ spark rate from 119 to 610 sparks/cell/s (P<.005).
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