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December 1, 2001AJP Cell Physiology

Micromolar Ca2+ from sparks activates Ca2+-sensitive K+ channels in rat cerebral artery smooth muscle

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Population

Isolated myocytes from rat cerebral arteries

Design

Preclinical

Key result

Ca2+ sparks increased BK channel activity up to 6 x 10^5-fold, indicating that local intracellular Ca2+ reaches micromolar levels to activate nearby BK channels in arterial smooth muscle cells.

Authors

GPGuillermo J. PérezABAdrian D. BonevMNMark T. Nelson

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Overview

Supports spark-BK coupling in isolated myocytes; leaves open physiological relevance for arterial tone regulation.

Structured PICO

P
Population
Isolated myocytes from rat cerebral arteries
E
Exposure
Laser scanning confocal microscopy and patch-clamp techniques to examine Ca2+ sparks and BK channels; application of 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid acetoxymethyl ester
O
Outcome
BK channel activity and local Ca2+ concentrationsurrogate

Local Ca2+ release events (sparks) deliver micromolar concentrations of Ca2+ to activate nearby BK channels in arterial smooth muscle cells.

Cite This Study

Pérez et al. (2001) studied this question. Ca2+ sparks was evaluated on BK channel activity. Ca2+ sparks increased BK channel activity up to 6 x 10^5-fold, indicating that local intracellular Ca2+ reaches micromolar levels to activate nearby BK channels in arterial smooth muscle cells.

synapsesocial.com/papers/6a4460b01851a54078f3d385https://doi.org/10.1152/ajpcell.2001.281.6.c1769
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