April 1, 1998The Journal of PhysiologyOpen Access

Intrasarcomere Ca2+ gradients and their spatio‐temporal relation to Ca2+sparks in rat cardiomyocytes

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Population

Rat cardiomyocytes

Design

Preclinical

Authors

HTHikaru TanakaOita University TSToshiyuki SekineTeikyo University TKToru KawanishiTokyo Institute of Technology

Discussion

Member takes

Implication

Supports spark summation model of Ca2+ release in animal cardiomyocytes; leaves open translation to human cardiac physiology.

Structured PICO

Population

Rat cardiomyocytes

Intervention

Electrical stimulation and observation using rapid-scanning laser confocal microscopy with fluo-3 and di-2-ANEPEQ

Outcome

Spatio-temporal relation of Ca2+ sparks and early phase of Ca2+ transients

This study provides visual evidence that Ca2+ release occurs from the junctional sarcoplasmic reticulum at the Z-line and suggests that normal Ca2+ transients may be the summation of individual Ca2+ sparks.

Cite This Study

Tanaka et al. (1998) studied this question.

synapsesocial.com/papers/6a75e71c49d3dc94b07860f8 https://doi.org/10.1111/j.1469-7793.1998.145br.x

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Intrasarcomere Ca2+ gradients and their spatio‐temporal relation to Ca2+sparks in rat cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Intrasarcomere Ca2+ gradients and their spatio‐temporal relation to Ca2+sparks in rat cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider