Key result
Spontaneous Ca2+ sparks in cat atrial cells result from the opening of multiple Ca2+ release channels clustered within discrete sarcoplasmic reticulum junctional regions.
Population
Dissociated cat atrial cells
Design
Preclinical
Authors
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No immediate clinical implications from cat atrial data; leaves open whether clustered channels mediate sparks in human myocardium.
Ca2+ sparks in cardiac muscle likely originate from the coordinated opening of multiple clustered Ca2+ release channels rather than single channels.
Blatter et al. (1997) studied Normal cardiac muscle physiology. Confocal microscopy observation of spontaneous Ca2+ sparks was evaluated on Ca2+ release flux underlying Ca2+ sparks. Spontaneous Ca2+ sparks in cat atrial cells result from the opening of multiple Ca2+ release channels clustered within discrete sarcoplasmic reticulum junctional regions.
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