Population
Mouse, rat, and human arterial smooth muscle cells and intact pressurized arteries
Design
Review
Authors
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May support Ca2+ spark targeting for vascular tone modulation; leaves open clinical translation in hypertension.
Elementary Ca2+ release units (Ca2+ sparks) play a key role in regulating arterial myogenic tone and may serve as novel therapeutic targets for modulating arterial smooth muscle function.
Gollasch et al. (2000) studied this question.
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