Key result
In human coronary artery myocytes, Ca2+ sparks exhibited a peak amplitude of 2.3, width of 2.27 microm, and duration of 62 ms, and were completely inhibited by 10 micromol/l ryanodine.
Population
Freshly-isolated, individual myocytes of human coronary arteries
Design
Preclinical
Authors
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First characterization of Ca2+ sparks in human coronary myocytes extends animal data; leaves open their role in vasoregulation.
This study provides the first evidence that calcium sparks occur in human coronary artery smooth muscle cells, with properties similar to but distinct from non-human models.
Fürstenau et al. (2000) studied this question. Ryanodine was evaluated on Ca2+ spark characteristics. In human coronary artery myocytes, Ca2+ sparks exhibited a peak amplitude of 2.3, width of 2.27 microm, and duration of 62 ms, and were completely inhibited by 10 micromol/l ryanodine.
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