Key result
8-bromo-cGMP inhibited single-channel activity of L-type Ca2+ channels in cultured chick embryonic cardiomyocytes, prolonging the slow time constant for the closed-time histogram from 6.7 to 15.4 msec.
Why the study?
Does 8-bromo-cGMP inhibit the activity of single calcium channels in cultured chick embryonic cardiomyocytes?
Does 8-bromo-cGMP inhibit the activity of single calcium channels in cultured chick embryonic cardiomyocytes?
cGMP inhibits L-type calcium channels in myocardial cells by prolonging the closed-time, suggesting it opposes the effects of cAMP.
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Supports cGMP opposing cAMP effects on cardiac Ca channels; leaves open relevance to adult human myocardium.
Tohse et al. (1991) studied Cultured chick embryonic cardiomyocytes. 8-bromo-cGMP vs. Control was evaluated on Single-channel activity of slow (L-type) Ca2+ channels. 8-bromo-cGMP inhibited single-channel activity of L-type Ca2+ channels in cultured chick embryonic cardiomyocytes, prolonging the slow time constant for the closed-time histogram from 6.7 to 15.4 msec.
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