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June 1, 2001The Journal of PhysiologyOpen Access

Cyclic GMP regulation of the L‐type Ca2+ channel current in human atrial myocytes

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Population

Human atrial myocytes

Comparison

Intracellular application of cGMP and various… vs Basal/control conditions

Design

Preclinical

Authors

GVGrégoire VandecasteeleHeart Failure / CardiomyopathyIVIgnácio VerdeUniversity of Beira InteriorCRCatherine Rücker‐MartinElectrophysiology

Discussion

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Implication

Biphasic cGMP regulation of atrial I(Ca) via PDE2/3 and PKA may affect calcium handling; leaves open targeted therapies pending human trials.

Structured PICO

P
Population
Human atrial myocytes
I
Intervention
Intracellular application of cGMP (0.5 microM and 5 microM) and various pharmacological agents (8-bromo-cGMP, KT 5823, PKI, cilostamide, EHNA)
C
Comparator
Basal/control conditions
O
Outcome
L-type Ca(2+) current (I(Ca))surrogate

Intracellular cGMP regulates basal L-type Ca2+ current in human atrial myocytes via modulation of cAMP levels and PKA activity through opposing actions on PDE2 and PDE3.

Cite This Study

Vandecasteele et al. (2001) studied this question.

synapsesocial.com/papers/6a7238f0fe4101aa97e0cb66https://doi.org/10.1111/j.1469-7793.2001.0329a.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor1996 · 213 citations
  2. 2Nitric oxide attenuates cardiac myocyte contraction1993 · 410 citations
  3. 3cGMP-Dependent Protein Kinase Regulation of the L-Type Ca 2+ Current in Rat Ventricular Myocytes1995 · 120 citations
  4. 4Contribution of phosphodiesterase isozymes to the regulation of the L‐type calcium current in human cardiac myocytes1997 · 39 citations
  5. 5Redox modulation of L-type calcium channels in ferret ventricular myocytes. Dual mechanism regulation by nitric oxide and S-nitrosothiols.1996 · 442 citations