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February 1, 1998The Journal of PhysiologyOpen Access

Role of the NO‐cGMP pathway in the muscarinic regulation of the L‐type Ca2+ current in human atrial myocytes

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Population

Freshly isolated human atrial myocytes

Comparison

Acetylcholine in the presence of nitric oxide… vs Acetylcholine under control conditions

Design

Preclinical

Authors

GVGrégoire VandecasteeleTEThomas EschenhagenRFRodolphe Fischmeister

Discussion

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Overview

Questions NO-cGMP role in muscarinic ICa control; leaves open contributions to other currents or human physiology.

Structured PICO

P
Population
Freshly isolated human atrial myocytes
I
Intervention
Acetylcholine (ACh) in the presence of nitric oxide synthase (NOS) inhibitors (L-NMMA) and guanylyl cyclase inhibitors (ODQ, Methylene Blue)
C
Comparator
Acetylcholine under control conditions (without inhibitors)
O
Outcome
L-type Ca2+ current (ICa)surrogate

The NO-cGMP pathway does not significantly contribute to the muscarinic regulation of the L-type Ca2+ current in human atrial myocytes.

Cite This Study

Vandecasteele et al. (1998) studied this question.

synapsesocial.com/papers/6a83d4465872f04c313e968ehttps://doi.org/10.1111/j.1469-7793.1998.653bv.x
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