Population
Cat atrial myocytes (n=23 for initial acetylcholine withdrawal experiment)
Comparison
Exposure to 1 microM acetylcholine for 2 min… vs Basal L-type Ca2+ current (control)
Design
Preclinical
Authors
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May guide mechanistic studies of post-cholinergic atrial recovery; leaves open relevance to human physiology or disease.
Nitric oxide signaling mediates the rebound stimulation of L-type Ca2+ current following acetylcholine withdrawal in cat atrial myocytes, suggesting a mechanism for rapid restoration of cardiac pacemaker and contractile functions after cholinergic suppression.
Wang et al. (1998) studied this question.
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