Key result
The nitric oxide donor SNAP increased basal L-type calcium current by 48% in right atrial myocytes from patients in sinus rhythm, but this stimulatory effect was significantly attenuated in patients with atrial fibrillation.
Population
Human right atrial myocytes from right atrial appendages of patients in sinus rhythm and atrial fibrillation
Comparison
NO donor S-nitroso-N-acetyl-penicillamine vs Baseline conditions without SNAP, and comparison…
Design
Preclinical
Authors
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May caution NO donor use in AF; leaves open PDE3-targeted arrhythmia research.
Absolute Event Rate: 48% vs 12%
p-value: p=<0.001
In atrial fibrillation, the stimulatory effect of nitric oxide on L-type calcium current is attenuated due to a loss of PDE3 regulation, while PDE2 regulation is preserved.
Rozmaritsa et al. (2013) studied Atrial Fibrillation (n=191). S-nitroso-N-acetyl-penicillamine (SNAP) vs. Baseline / Atrial fibrillation cells was evaluated on Change in L-type calcium current (ICa,L) after exposure to SNAP (p=<0.001). The nitric oxide donor SNAP increased basal L-type calcium current by 48% in right atrial myocytes from patients in sinus rhythm, but this stimulatory effect was significantly attenuated in patients with atrial fibrillation.
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