March 1, 1997Cardiovascular ResearchOpen Access

Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells

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Population

Enzymatically isolated adult and newborn (1-4-day-old) rabbit ventricular myocytes

Comparison

Intracellular perfusion of cGMP analogs… vs Basal conditions and comparison between adult…

Design

Preclinical

Authors

RKRajiv KumarNational Institute of Technology Jamshedpur TNTakao NamikiChiba University Hospital RJRonald W. JoynerUniversity of Iowa

Discussion

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Implication

Animal data show developmental ICa regulation by cGMP; leaves open human neonatal relevance.

Structured PICO

Population

Enzymatically isolated adult and newborn (1-4-day-old) rabbit ventricular myocytes

Intervention

Intracellular perfusion of cGMP analogs (8BrcGMP, 8CPT-cGMP), guanylyl cyclase inhibitors (methylene blue, LY-83583), PKG inhibitor (KT-5823), and nitric oxide donor (nitrosoglutathione)

Comparator

Basal conditions and comparison between adult and newborn cells

Outcome

Modulation of basal L-type calcium current (ICa) measured under whole-cell voltage clamp conditionssurrogate

cGMP plays a crucial role in maintaining basal L-type calcium current in newborn rabbit ventricular cells via a PKG-dependent mechanism, an effect that is absent in adult cells.

Cite This Study

Kumar et al. (1997) studied this question.

synapsesocial.com/papers/6a7238f0fe4101aa97e0cb68 https://doi.org/10.1016/s0008-6363(96)00258-1

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Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of cGMP on L-type calcium current of adult and newborn rabbit ventricular cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider