Key result
Internal application of cGMP-dependent protein kinase inhibited basal L-type Ca2+ channel current by an average of 42.1% in rat ventricular myocytes.
cGMP-dependent protein kinase directly inhibits L-type Ca2+ channels in rat ventricular myocytes, suggesting a balance between PK-A and PK-G activities in regulating slow Ca2+ channels.
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May guide mechanistic studies of cGMP-PKG in cardiomyocytes; leaves open human relevance and therapeutic translation.
Sumii et al. (1995) studied this question. cGMP-dependent protein kinase (PK-G) vs. Basal level was evaluated on Inhibition of basal L-type Ca2+ channel current. Internal application of cGMP-dependent protein kinase inhibited basal L-type Ca2+ channel current by an average of 42.1% in rat ventricular myocytes.
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