Population
Enzymatically isolated adult rabbit atrial and ventricular cells
Comparison
Pharmacological modulation of the cGMP/PKG pathway vs Baseline or control conditions without specific…
Design
Preclinical
Authors
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PKG-dependent I(Ca) modulation in rabbit atria extends mechanistic insights; leaves open translation to human electrophysiology or therapy.
In rabbit atrial cells, cGMP stimulates L-type calcium current via PKG-dependent mechanisms, and PKG activity appears necessary for full beta-adrenergic stimulation of this current.
Yanfang Wang (2000) studied this question.
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