Key result
Protein kinase G (PKG) activation increased ATP-sensitive K(+) channel activity in rabbit ventricular myocytes via PKG-dependent phosphorylation, whereas protein kinase A had no effect.
K(ATP) channels in rabbit ventricular myocytes are regulated by a PKG-signaling pathway via PKG-dependent phosphorylation, which may contribute to ischemic preconditioning.
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May link PKG to ischemic preconditioning via K(ATP) channels; hypothesis-generating for human cardioprotection.
Han et al. (2001) studied this question. Protein kinase G (PKG) activation vs. PKG inhibition or PKA activation was evaluated on ATP-sensitive K(+) (K(ATP)) channel activity. Protein kinase G (PKG) activation increased ATP-sensitive K(+) channel activity in rabbit ventricular myocytes via PKG-dependent phosphorylation, whereas protein kinase A had no effect.
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