November 1, 1996AJP Cell Physiology

Mechanism of activation by cGMP-dependent protein kinase of large Ca(2+)-activated K+ channels in mesangial cells

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Population

Human mesangial cells

Comparison

cGMP-dependent protein kinase activation vs Control conditions

Design

Preclinical

Authors

JSJames D. StockandThe University of Texas Health Science Center at San Antonio SSSteven C. SansomUniversity of Nebraska Medical Center

Discussion

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Implication

May modulate mesangial cell function in renal models; leaves open translation to human physiology or therapy.

Structured PICO

Population

Human mesangial cells

Intervention

cGMP-dependent protein kinase (PKG) activation (via DBcGMP, cGMP + MgATP, or exogenous PKG)

Comparator

Control conditions (absence of PKG, presence of inhibitors like staurosporine or KT-5823, or cAMP + MgATP)

Outcome

Open probability (Po) of large Ca(2+)-activated K+ channels (BKCa), half-activation potential (V1/2), and Ca1/2surrogate

This study demonstrates that endogenous PKG activates BKCa channels in human mesangial cells by lowering their calcium and voltage activation thresholds.

Cite This Study

Stockand et al. (1996) studied this question.

synapsesocial.com/papers/6a85aac29df929a58fada809 https://doi.org/10.1152/ajpcell.1996.271.5.c1669

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Mechanism of activation by cGMP-dependent protein kinase of large Ca(2+)-activated K+ channels in mesangial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of activation by cGMP-dependent protein kinase of large Ca(2+)-activated K+ channels in mesangial cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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