Population
HEK293 cells expressing BK channel isoforms (BK(A), BK(B), and BK(C)) cloned from tracheal smooth muscle
Comparison
Stimulation with cGMP kinase or cAMP kinase… vs Different BK channel isoforms, unmutated…
Design
Preclinical
Authors
Loading...
PKC phosphorylation switches BK channel regulation between cGMP and cAMP pathways in smooth muscle; extends mechanistic insight but leaves open human relevance.
Phosphorylation by PKC acts as a molecular switch determining whether BK channels in smooth muscle are stimulated by cGMP or cAMP pathways.
Zhou et al. (2001) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: