April 28, 2000Circulation Research

cAMP-Dependent Vasodilators Cross-Activate the cGMP-Dependent Protein Kinase to Stimulate BKCaChannel Activity in Coronary Artery Smooth Muscle Cells

View Full Paper

Ask AI

Bookmark

Population

Single myocytes from coronary arteries

Comparison

cAMP-stimulating agents vs Inhibitors of PKG or PKA, and cell-free patches…

Design

Preclinical

Authors

RWRichard E. WhiteThe Ohio State University Wexner Medical Center JKJonathan P. KrymanWright State University AEAbdalla M. El‐MowafyFuture University in Egypt

Discussion

Member takes

Implication

Identifies potential coronary vasodilator targets in animal models; leaves open human translation and clinical relevance.

Structured PICO

Population

Single myocytes from coronary arteries

Intervention

cAMP-stimulating agents (10 micromol/L isoproterenol, forskolin, dopamine, or CPT-cAMP)

Comparator

Inhibitors of PKG (KT5823; Rp-8-pCPT-cGMPS) or PKA, and cell-free patches with purified PKG or PKA

Outcome

BK(Ca) channel activity and PKG activitysurrogate

This study identifies a novel signaling pathway where cAMP-dependent vasodilators regulate potassium channel activity in vascular smooth muscle via cross-activation of PKG.

Cite This Study

White et al. (2000) studied this question.

synapsesocial.com/papers/6a82c563d88fdfcf4fa0cb8e https://doi.org/10.1161/01.res.86.8.897

View Full Paper

Ask AI

Bookmark

cAMP-Dependent Vasodilators Cross-Activate the cGMP-Dependent Protein Kinase to Stimulate BKCaChannel Activity in Coronary Artery Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

cAMP-Dependent Vasodilators Cross-Activate the cGMP-Dependent Protein Kinase to Stimulate BKCaChannel Activity in Coronary Artery Smooth Muscle Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider