November 1, 1999Journal of Cardiovascular Pharmacology

A Novel Transduction Mechanism Mediating Dopamine-Induced Vascular Relaxation: Opening of BKCa Channels by Cyclic AMP-Induced Stimulation of the Cyclic GMP-Dependent Protein Kinase

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Why the study?

Does dopamine induce vascular relaxation in porcine coronary arteries via a specific signal transduction pathway?

Population

Isolated porcine coronary arteries and single arterial myocytes

Comparison

Dopamine or fenoldopam (a selective DA-1 agonist) vs Control conditions and various pharmacological…

Design

Preclinical

Authors

GHGuichun HanUniversity of Pikeville JKJonathan P. KrymanWright State University PMPatricia J.P. McMillin

Discussion

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Implication

Elucidates DA-1/PKG/BKCa pathway in porcine coronary arteries; leaves open translation to human vasomotor control.

Structured PICO

Does dopamine induce vascular relaxation in porcine coronary arteries via a specific signal transduction pathway?

Population

Isolated porcine coronary arteries and single arterial myocytes

Intervention

Dopamine or fenoldopam (a selective DA-1 agonist)

Comparator

Control conditions and various pharmacological inhibitors (iberiotoxin, DA-1-receptor antagonist, propranolol, adenylyl cyclase inhibitor, PKA inhibitor, PKG inhibitor)

Outcome

Vascular relaxation and BKCa channel opening probabilitysurrogate

Dopamine-induced coronary vasodilation is mediated by DA-1 receptor activation of BKCa channels through a novel cross-reactivity mechanism involving cAMP-dependent stimulation of PKG.

Cite This Study

Han et al. (1999) studied this question.

synapsesocial.com/papers/6a826522a8461dff0846cd45 https://doi.org/10.1097/00005344-199911000-00001

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A Novel Transduction Mechanism Mediating Dopamine-Induced Vascular Relaxation: Opening of BKCa Channels by Cyclic AMP-Induced Stimulation of the Cyclic GMP-Dependent Protein Kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Novel Transduction Mechanism Mediating Dopamine-Induced Vascular Relaxation: Opening of BKCa Channels by Cyclic AMP-Induced Stimulation of the Cyclic GMP-Dependent Protein Kinase

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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