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January 1, 1996Clinical and Experimental Pharmacology and Physiology

SYMPOSIUM: Experimental Biology 1995 Role of Mesangial Cell Ion Transport in Glomerular Physiology and Disease: PHYSIOLOGICAL ROLE OF LARGE, Ca2+‐ACTIVATED K+CHANNELS IN HUMAN GLOMERULAR MESANGIAL CELLS

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Key result

Large Ca2+-activated K+ channels have a minimal role in regulating resting mesangial cell tone but are markedly enhanced by cGMP-stimulating relaxants and arachidonic acid.

Population

Human glomerular mesangial cells (MC) in culture

Comparison

Pharmacological manipulation with angiotensin… vs Control conditions

Design

Preclinical

Authors

SSSteven C. SansomJSJames D. Stockand

Discussion

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Overview

Animal data indicate minimal basal BKCa role in mesangial tone; leaves open cGMP/AA enhancement as hypothesis-generating for renal research.

Structured PICO

P
Population
Human glomerular mesangial cells (MC) in culture
I
Intervention
Pharmacological manipulation with angiotensin II, glybenclamide, iberiotoxin, nitroprusside, ANP, db-cGMP, arachidonic acid, and high glucose
C
Comparator
Control conditions (absence of specific pharmacological agents)
O
Outcome
Mesangial cell contractile tone and K+ channel activitysurrogate

In human glomerular mesangial cells, large Ca2+-activated K+ channels play a minimal role in regulating resting tone but are significantly activated by cGMP-stimulating relaxants and arachidonic acid.

Cite This Study

Sansom et al. (1996) studied Glomerular Physiology. Iberiotoxin (IbTX) and other K+ channel modulators vs. Control solutions was evaluated on Mesangial cell contractile tone and K+ channel activity. Large Ca2+-activated K+ channels have a minimal role in regulating resting mesangial cell tone but are markedly enhanced by cGMP-stimulating relaxants and arachidonic acid.

synapsesocial.com/papers/6a99ee331aede4d0e945ac49https://doi.org/10.1111/j.1440-1681.1996.tb03066.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Large Ca(2+)-activated K+ channels responsive to angiotensin II in cultured human mesangial cells1994 · 50 citations
  2. 2Calcium-activated potassium channels from coronary smooth muscle reconstituted in lipid bilayers1991 · 52 citations
  3. 3Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet-activating factor and endothelin is attenuated by prostaglandin E21990 · 27 citations
  4. 4Both membrane stretch and fatty acids directly activate large conductance Ca<sup>2+</sup>‐activated K<sup>+</sup> channels in vascular smooth muscle cells1992 · 204 citations
  5. 5ANF inhibits vasopressin-induced Ca2+ mobilization and contraction in glomerular mesangial cells1988 · 22 citations