Key result
Addition of 100 nM angiotensin II increased the open probability of large Ca2+-activated K+ channels in cultured human mesangial cells by decreasing the time constant of the slow closed state.
Population
Cultured human mesangial cells (subpassages)
Comparison
Angiotensin II (100 nM) added to bath solution vs Baseline conditions
Design
Preclinical
Authors
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Does not inform clinical practice; leaves open BK channel role in glomerular function in vivo.
Large Ca2+-activated K+ channels in human mesangial cells are activated by angiotensin II, suggesting a role in membrane repolarization following agonist-induced intracellular Ca2+ mobilization.
Stockand et al. (1994) studied Human mesangial cell cultures. Angiotensin II was evaluated on Open probability (Po) of large K+ channels (MKCa). Addition of 100 nM angiotensin II increased the open probability of large Ca2+-activated K+ channels in cultured human mesangial cells by decreasing the time constant of the slow closed state.
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