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January 1, 2003AJP Renal Physiology

Angiotensin II stimulates basolateral K channels in rat cortical collecting ducts

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Population

Rat cortical collecting ducts (CCDs)

Design

Preclinical

Authors

YWYuan WeiChinese University of Hong Kong, ShenzhenWWWen‐Hui WangUniversity of Science and Technology of China

Discussion

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Implication

Extends ANG II-AT1-NO effects on renal K channels in rats; leaves open translation to human tubular function or hypertension.

Structured PICO

P
Population
Rat cortical collecting ducts (CCDs)
I
Intervention
Angiotensin II (100 pM-100 nM)
O
Outcome
Activity of basolateral 18-pS K channelssurrogate

Angiotensin II stimulates basolateral K-channel activity in rat cortical collecting ducts via AT1 receptors and a nitric oxide-dependent cGMP pathway.

Cite This Study

Wei et al. (2003) studied this question.

synapsesocial.com/papers/6a886fc1138f07bd6f14bb15https://doi.org/10.1152/ajprenal.00211.2002
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1NO/cGMP signaling modulates regulation of Na+-K+-ATPase activity by angiotensin II in rat proximal tubules2001 · 39 citations
  2. 2Atrial Natriuretic Peptide Inhibits a Cation Channel in Renal Inner Medullary Collecting Duct Cells1989 · 231 citations
  3. 3Neuronal nitric oxide synthase is expressed in principal cell of collecting duct1998 · 43 citations
  4. 4Role of protein kinase C in proximal bicarbonate absorption and angiotensin signaling1990 · 85 citations
  5. 5Conductance and gating of epithelial Na channels from rat cortical collecting tubule. Effects of luminal Na and Li.1988 · 106 citations