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March 1, 1990AJP Heart and Circulatory Physiology

ANG II inhibits calcium-activated potassium channels from coronary smooth muscle in lipid bilayers

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Population

Calcium-activated potassium channels from coronary smooth muscle incorporated into lipid bilayers

Design

Preclinical

Authors

LTL. ToroSanté Publique FranceMAMariano AmadorBaylor College of MedicineESEnrico StefaniMinistry of Economy, Trade and Industry

Discussion

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Overview

Supports direct ANG II vasoconstriction via coronary KCa inhibition; hypothesis-generating in animals, requires human validation.

Structured PICO

P
Population
Calcium-activated potassium (KCa) channels (congruent to 250 pS) from coronary smooth muscle incorporated into lipid bilayers
I
Intervention
Externally applied Angiotensin II (ANG II)
O
Outcome
Regulation of K+ channels at the single-channel level (inhibition, open/closed states)surrogate

Angiotensin II directly inhibits calcium-activated potassium channels in coronary smooth muscle, providing a mechanism for its vasoconstrictive effects.

Cite This Study

Toro et al. (1990) studied this question.

synapsesocial.com/papers/6a8a8b4a51cd0cd12ac1577dhttps://doi.org/10.1152/ajpheart.1990.258.3.h912
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II inhibits and alters kinetics of voltage-gated K+channels of rat arterial smooth muscle2001 · 77 citations
  2. 2Angiotensin II stimulates basolateral K channels in rat cortical collecting ducts2003 · 19 citations
  3. 3Intracellular Angiotensin II Stimulates Voltage-Operated Ca 2+ Channels in Arterial Myocytes2002 · 25 citations
  4. 4Angiotensin II stimulates basolateral 50-pS K channels in the thick ascending limb2013 · 6 citations
  5. 5Angiotensin II stimulates cardiac L-type Ca2+current by a Ca2+- and protein kinase C-dependent mechanism2001 · 74 citations