Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 1, 2001AJP Heart and Circulatory Physiology

Angiotensin II inhibits and alters kinetics of voltage-gated K+channels of rat arterial smooth muscle

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does angiotensin II alter voltage-gated K+ channels in rat arterial smooth muscle cells?

Population

Isolated rat arterial smooth muscle cells

Comparison

Angiotensin II and various kinase inhibitors vs Control conditions without specific inhibitors

Design

Preclinical

Authors

YHYasunobu HayabuchiTokushima University HospitalNSN. B. StandenLa Trobe UniversityNDNoel W. DaviesGoogle (United States)

Discussion

Loading...

Member takes

Implication

Should not yet change practice; leaves open whether ANG II-PKC/PKA signaling modulates arterial tone in vivo.

Structured PICO

Does angiotensin II alter voltage-gated K+ channels in rat arterial smooth muscle cells?

P
Population
Isolated rat arterial smooth muscle cells
I
Intervention
Angiotensin II (100 nM) and various kinase inhibitors (losartan, PKA inhibitor, PKC inhibitors)
C
Comparator
Control conditions without specific inhibitors
O
Outcome
Voltage-gated K+ currents (I(K(V))) recorded using patch-clamp techniquessurrogate

Angiotensin II inhibits voltage-gated potassium channels in rat arterial smooth muscle via activation of PKC-epsilon and inhibition of PKA.

Cite This Study

Hayabuchi et al. (2001) studied this question.

synapsesocial.com/papers/6a20ec60c9150832be18137chttps://doi.org/10.1152/ajpheart.2001.281.6.h2480
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phosphorylation by protein kinase A enhances delayed rectifier K+ current in rabbit vascular smooth muscle cells1995 · 130 citations
  2. 2Modulatory Effects of Arachidonic Acid on the Delayed Rectifier K+Current in Rat Pulmonary Arterial Myocytes1996 · 43 citations
  3. 3Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells.1986 · 491 citations
  4. 4ACTIONS OF 4‐AMINOPYRIDINE ON VASCULAR SMOOTH MUSCLE TISSUES OF THE GUINEA‐PIG1980 · 99 citations
  5. 5Angiotensin II activation of protein kinase C decreases delayed rectifier K+ current in rabbit vascular myocytes.1996 · 99 citations