Key result
Angiotensin II reduces KV1.5 surface abundance and currents in arterial myocytes via PKC-dependent degradation.
Angiotensin II promotes vasoconstriction by stimulating protein kinase C-dependent lysosomal degradation of KV1.5 channels, reducing their functional abundance at the myocyte surface.
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Reduces KV1.5 surface abundance in arterial myocytes; extends isoform-selective KV regulation but leaves open in vivo vascular effects.
Kidd et al. (2016) studied this question. Angiotensin II was evaluated on Surface and total KV1.5 protein abundance and whole-cell KV currents. Angiotensin II stimulates protein kinase C-dependent degradation of KV1.5 channels, reducing their surface abundance and whole-cell currents in arterial myocytes.
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