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April 1, 1998AJP Cell Physiology

Activation of Ca2+-activated K+(maxi-K+) channel by angiotensin II in myocytes of the guinea pig ileum

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Population

Freshly dispersed intestinal myocytes from guinea pig ileum

Design

Preclinical

Authors

FRFernando RomeroUniversidad Técnica Particular de LojaBSBagnólia Araújo da SilvaUniversidade Federal da ParaíbaVNViviane L. A. NouailhetasAdvanced Research Projects Agency - Energy

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Overview

Extends AT1 signaling models in animal smooth muscle; leaves open human translation or therapeutic relevance.

Structured PICO

P
Population
Freshly dispersed intestinal myocytes from guinea pig ileum
I
Intervention
Angiotensin II (ANG II) and its synthetic analog, [Lys2]ANG II
O
Outcome
Activation of maxi-K+ channels and intracellular Ca2+ concentrationsurrogate

Angiotensin II activates maxi-K+ channels in guinea pig ileum myocytes via AT1 receptors and increased intracellular calcium, providing a model for transmembrane signaling.

Cite This Study

Romero et al. (1998) studied this question.

synapsesocial.com/papers/6a83874ab397c5df40cd7d0ahttps://doi.org/10.1152/ajpcell.1998.274.4.c983
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANG II inhibits calcium-activated potassium channels from coronary smooth muscle in lipid bilayers1990 · 83 citations
  2. 2The activation of calcium and calcium‐activated potassium channels in mammalian colonic smooth muscle by substance P.1990 · 55 citations
  3. 3Emptying and refilling of Ca2+ store in tracheal myocytes as indicated by ACh-evoked currents and contraction1993 · 74 citations
  4. 4Stimulation of inositol trisphosphate formation in hepatocytes by vasopressin, adrenaline and angiotensin II and its relationship to changes in cytosolic free Ca2+1985 · 214 citations
  5. 5Muscarinic inhibition of single KCa channels in smooth muscle cells by a pertussis-sensitive G protein1991 · 107 citations