Key result
Angiotensin II at 10(-12) M enhanced initial Ca(2+) uptake in the proximal and distal convoluted tubules of the rabbit, increasing maximal velocity from 0.72 to 0.90 pmol/microg/10s (P<0.05).
Why the study?
Does angiotensin II increase calcium reabsorption in the proximal and distal convoluted tubules of the rabbit kidney?
Population
Rabbit proximal (PT) and distal (DT) convoluted tubules (luminal membranes)
Comparison
Angiotensin II at various concentrations vs Baseline/control without ANG II, or with…
Design
Preclinical
Authors
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May influence tubular calcium transport via AT1 receptors in rabbits; hypothesis-generating for human renal physiology.
Does angiotensin II increase calcium reabsorption in the proximal and distal convoluted tubules of the rabbit kidney?
Absolute Event Rate: 0.9% vs 0.72%
p-value: p=< 0.05
Angiotensin II enhances calcium reabsorption in the proximal and distal convoluted tubules of the rabbit kidney, acting via AT1 receptors.
Charbonneau et al. (2001) studied this question. Angiotensin II was evaluated on Ca(2+) uptake by the luminal membranes of the proximal and distal convoluted tubules (p=< 0.05). Angiotensin II at 10(-12) M enhanced initial Ca(2+) uptake in the proximal and distal convoluted tubules of the rabbit, increasing maximal velocity from 0.72 to 0.90 pmol/microg/10s (P<0.05).
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