Why the study?
Does Angiotensin II activate specific transduction pathways via AT1 or AT2 receptors in rat proximal tubule cells?
Does Angiotensin II activate specific transduction pathways via AT1 or AT2 receptors in rat proximal tubule cells?
This study demonstrates that AT1 receptors, but not AT2 receptors, are present in intact rat proximal tubule cells and are coupled to both IPs-Ca2+ and cAMP signaling pathways.
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AT1-selective ANG II signaling in rat tubules supports targeted mechanistic studies; leaves open human translation and clinical relevance.
Poggioli et al. (1992) studied this question.
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