Key result
In proximal tubule cells, Angiotensin II AT2 receptor activation inhibited MAPK activity and mitogenesis via phosphatase activation, while stimulating apoptosis through a distinct pathway.
Population
Proximal tubule cell line LLC-PK(1) transfected with a plasmid containing cDNA for the rat AT(2) receptor
Comparison
Angiotensin II (ANG II) (10(-7) M) vs Control conditions, AT antagonist PD-123319, AT…
Design
Preclinical
Authors
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Does not inform clinical renal care; leaves open whether AT2 pathways regulate human proximal tubule growth or apoptosis.
AT2 receptors in proximal tubule cells inhibit cell growth via distinct signaling pathways, including phosphatase-dependent inhibition of mitogenesis and phosphatase-independent stimulation of apoptosis.
Zimpelmann et al. (2001) studied this question. Angiotensin II was evaluated on MAPK activity, phosphotyrosine phosphatase activity, mitogenesis, and apoptosis. In proximal tubule cells, Angiotensin II AT2 receptor activation inhibited MAPK activity and mitogenesis via phosphatase activation, while stimulating apoptosis through a distinct pathway.