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November 1, 1996Hypertension

Angiotensin II Type 2 Receptor Inhibits Cell Proliferation and Activates Tyrosine Phosphatase

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Population

R3T3 fibroblast cells and AT2 gene-null mice

Comparison

AT2 gene knockout and selective AT2 antagonists vs null

Design

Preclinical

Authors

STSatoshi TsuzukiKyoto UniversityTMTeruyoshi MatobaNara Women's UniversitySESatoru EguchiVascular Medicine

Discussion

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Implication

AT2's dual BP and antiproliferative effects in mice are hypothesis-generating; human therapeutic relevance remains open.

Structured PICO

P
Population
R3T3 fibroblast cells and AT2 gene-null mice
I
Intervention
AT2 gene knockout and selective AT2 antagonists
C
Comparator
null
O
Outcome
Cell proliferation, phosphotyrosine phosphatase activation, and blood pressure regulationsurrogate

The AT2 receptor acts as a mitogen inhibitor and has a hypotensive action, though it also suppresses pressure natriuresis, suggesting a complex role in blood pressure regulation and sodium metabolism.

Cite This Study

Tsuzuki et al. (1996) studied this question.

synapsesocial.com/papers/6a7dbac0d0946debe9150242https://doi.org/10.1161/01.hyp.28.5.916
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transfer.1995 · 681 citations
  2. 2Molecular cloning of a novel angiotensin II receptor isoform involved in phosphotyrosine phosphatase inhibition.1993 · 716 citations
  3. 3The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cells.1995 · 915 citations
  4. 4Subtype 2 of angiotensin II receptors controls pressure-natriuresis in rats.1995 · 139 citations
  5. 5The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious rats.1996 · 313 citations