What question did this study set out to answer?

To review the cellular localization, expression regulation, and pathophysiological actions of the angiotensin II type 2 receptor in cardiovascular and renal systems.

December 14, 1998Circulation ResearchOpen Access

Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases

Q: What is the clinical evidence from this study?

Study design: Review. Population: Cardiovascular and renal diseases. Intervention: Angiotensin II type 2 receptor (AT2-R).

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Key result

Angiotensin II type 2 receptor (AT2-R) mediates cardioprotection, vasodilation, and pressure natriuresis, counteracting tissue remodeling in cardiovascular and renal diseases.

Design

Review

Authors

HMHiroaki MatsubaraUniversity of Notre Dame

Discussion

Member takes

Implication

May support AT2-R agonism in CV/renal disease; leaves open selective agonist trials for clinical translation.

Key Points

To review the cellular localization, expression regulation, and pathophysiological actions of the angiotensin II type 2 receptor in cardiovascular and renal systems.
Synthesis of mechanistic evidence from cell-specific transgenic mouse models overexpressing the angiotensin II type 2 receptor.
Evaluation of downstream signaling pathways, including Gi protein-dependent phosphatases and the kinin/nitric oxide/cGMP cascade.
Comparison of receptor expression profiles between rodent and human cardiovascular tissues under physiological and pathological conditions.
Re-expression of the receptor during vascular injury and heart failure inhibits growth factor-induced mitogen signals and extracellular matrix protein synthesis while promoting programmed cell death.
Cardiac- and vascular-specific overexpression blunts chronotropic and pressor responses to angiotensin II, stimulating vasodilation, cardioprotection, and pressure natriuresis through kinin/nitric oxide/cGMP activation.
Higher basal expression of the receptor in human hearts relative to rodents indicates enhanced therapeutic relevance during clinical treatment with type 1 receptor antagonists.

PICO

Population

Cardiovascular and renal diseases

Intervention / Comparator

Angiotensin II type 2 receptor (AT2-R)

This review highlights the cardioprotective, vasodilatory, and tissue-remodeling inhibitory roles of the Angiotensin II Type 2 receptor in cardiovascular and renal diseases.

Cite This Study

Hiroaki Matsubara (1998) conducted a review in Cardiovascular and renal diseases. Angiotensin II type 2 receptor (AT2-R) was evaluated. Angiotensin II type 2 receptor (AT2-R) mediates cardioprotection, vasodilation, and pressure natriuresis, counteracting tissue remodeling in cardiovascular and renal diseases.

synapsesocial.com/papers/6a15984779ff98d0de4edcd5 https://doi.org/10.1161/01.res.83.12.1182

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Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases

Discussion

Member takes

Implication

Key Points

PICO

Cite This Study

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