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The angiotensin II type 2 receptor plays a protective role by counteracting the type 1 receptor, and the recent development of nonpeptide agonists opens new avenues for investigating its therapeutic potential.
The angiotensin II type 2 (AT 2 R) receptor is highly expressed during fetal development but rapidly declines with aging and is limited to certain organs. However, this receptor is reexpressed in response stress or injury. AT 2 R is believed to play a protective role by counteracting the effects of the angiotensin II type 1 receptor. AT 2 R enhances vasodilation, renal sodium excretion, and nitric oxide production. AT 2 R also has antiproliferation, antihypertrophy, and anti‐inflammation effects. The role of AT 2 R in human health and disease is not well established yet, mainly due to the lack of tools to manipulate this receptor. With the recent development of an AT 2 R nonpeptide agonist, the function of this receptor and its role in disease management is being investigated.
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Helmy M. Siragy (2009) studied this question.
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