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March 15, 2017Journal of Drug Delivery and TherapeuticsOpen Access

The Role of Angiotensin Ii Type 2 Receptors (At2rs) in the Regulation of Cardio-Renal and Neuroprotective Activities: Potential Therapeutic Implications

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Design

Review

Key result

Stimulation of angiotensin II type 2 receptors mediates cardio-renal and neuroprotective functions through antiproliferative, anti-inflammatory, vasodilation, and natriuresis effects.

Authors

YMYalew MollaMSMekonnen Sisay

Discussion

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Member takes

Overview

Should not yet change practice; leaves open therapeutic targeting of AT2 receptors pending randomized trials.

PICO

P
Population
Cardiovascular, renal, and brain dysfunctions
I
Intervention / Comparator
Angiotensin II type 2 receptor (AT2R) stimulation

AT2R stimulation represents a potential therapeutic target for cardiovascular, renal, and neurological disorders due to its counter-regulatory effects against AT1R.

Limitations

  • Further studies have to be conducted that can show the molecular signal transduction involving effects mediated by the AT2R.

Cite This Study

Molla et al. (2017) conducted a review in Cardiovascular, renal, and brain dysfunctions. Angiotensin II type 2 receptor (AT2R) stimulation was evaluated. Stimulation of angiotensin II type 2 receptors mediates cardio-renal and neuroprotective functions through antiproliferative, anti-inflammatory, vasodilation, and natriuresis effects.

synapsesocial.com/papers/6a6beff1b47c2e26b424347fhttps://doi.org/10.22270/jddt.v7i2.1356
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathophysiological Role of Angiotensin II Type 2 Receptor in Cardiovascular and Renal Diseases1998 · 479 citations
  2. 2Angiotensin II type 2 receptor (AT2R) in renal and cardiovascular disease2016 · 87 citations
  3. 3Angiotensin II Type 2 Receptor: A Target for Protection Against Hypertension, Metabolic Dysfunction, and Organ Remodeling2021 · 72 citations
  4. 4AT2 receptors in cardiovascular and renal diseases2017 · 116 citations
  5. 5Cardiovascular and renal function of angiotensin II type-2 receptors2004 · 85 citations