Design
Review
Key result
The angiotensin II type 2 receptor (AT2R) regulates tissue and organ development and provides a potential counter-regulatory mechanism against AT1R-mediated actions in renal and cardiovascular systems.
Authors
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Highlights AT2R as potential cardiorenal therapeutic target; leaves open clinical validation in prospective trials.
This review provides insights into the biological role of the AT2R, emphasizing its potential counter-regulatory effects against AT1R-mediated actions in renal and cardiovascular diseases.
Chow et al. (2016) conducted a review in Renal and cardiovascular disease. Angiotensin II type 2 receptor (AT2R) was evaluated. The angiotensin II type 2 receptor (AT2R) regulates tissue and organ development and provides a potential counter-regulatory mechanism against AT1R-mediated actions in renal and cardiovascular systems.