Population
LLC-PK1/Cl4 cells transfected with an expression plasmid containing cDNA encoding the rabbit AT1 ANG II…
Comparison
Angiotensin II applied apically or basolaterally vs Wild-type LLC-PK1/Cl4 cells or untreated…
Design
Preclinical
Authors
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ANG II may stimulate renal epithelial growth via dual-membrane receptors; leaves open its role in tubular hypertrophy or remodeling in vivo.
In renal epithelial cells, AT1 ANG II receptors sort to both apical and basolateral membranes, coupling to phospholipase C and stimulating protein synthesis via G proteins and S6 kinase.
Burns et al. (1995) studied this question.
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