January 1, 1993Nephrology Dialysis Transplantation

Angiotensin II stimulates cellular hypertrophy of LLC-PK1 cells through the AT1 receptor

View Full Paper

Ask AI

Bookmark

Why the study?

Does angiotensin II induce cellular hypertrophy in LLC-PK1 cells?

Population

Pig tubular epithelial cell line LLC-PK1

Design

Preclinical

Authors

GWGerald WolfUniversity of Cologne GZGunther ZahnerUniversität Hamburg UMUlrich F. MondorfGoethe University Frankfurt

Discussion

Member takes

Implication

Should not change clinical practice; hypothesis-generating for AT1-mediated tubular hypertrophy in renal disease progression.

Structured PICO

Does angiotensin II induce cellular hypertrophy in LLC-PK1 cells?

Population

Pig tubular epithelial cell line LLC-PK1

Intervention

Angiotensin II (10(-6)-10(-10) M)

Outcome

Cellular hypertrophy (assessed by increases in de novo protein synthesis, total protein, and RNA content) and proliferation (measured by [3H]thymidine incorporation)surrogate

Angiotensin II acts as a hypertrophogenic growth factor for tubular epithelial cells via the AT1 receptor, suggesting a mechanism for its role in the progression of renal failure.

Cite This Study

Wolf et al. (1993) studied this question.

synapsesocial.com/papers/6a766349f6749a0058ec0200 https://doi.org/10.1093/oxfordjournals.ndt.a092404

View Full Paper

Ask AI

Bookmark

Angiotensin II stimulates cellular hypertrophy of LLC-PK1 cells through the AT1 receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Angiotensin II stimulates cellular hypertrophy of LLC-PK1 cells through the AT1 receptor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider