Key result
Stimulation of the AT2 receptor inhibited AT1 receptor-mediated tyrosine phosphorylation of STATs and ERK activation in vascular smooth muscle cells and fibroblasts.
Why the study?
Does AT2 receptor stimulation inhibit AT1 receptor-mediated STAT activation in vascular smooth muscle cells?
Population
AT2 receptor cDNA-transfected rat adult vascular smooth muscle cells, R3T3 fibroblasts, and mouse fetal VSMCs
Comparison
Stimulation of Angiotensin II type 2 receptor vs null
Design
Preclinical
Authors
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May limit AT1-driven vascular proliferation; leaves open clinical translation of AT2 agonism.
Does AT2 receptor stimulation inhibit AT1 receptor-mediated STAT activation in vascular smooth muscle cells?
AT2 receptor stimulation negatively crosstalks with multiple growth receptors by inhibiting ERK and STAT activation, providing a molecular mechanism for its inhibitory action on cell growth.
Horiuchi et al. (1999) studied this question. AT2 receptor stimulation was evaluated on STAT and ERK activation. Stimulation of the AT2 receptor inhibited AT1 receptor-mediated tyrosine phosphorylation of STATs and ERK activation in vascular smooth muscle cells and fibroblasts.
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