Key result
Transfection of the AT2 receptor downregulated AT1a and TGF-beta type I receptors in normal VSMCs from WKY rats, but failed to downregulate these receptors in VSMCs from spontaneously hypertensive rats.
Why the study?
Does AT2 receptor overexpression downregulate AT1a and TGF-beta receptors in VSMCs from spontaneously hypertensive rats compared to normotensive rats?
Does AT2 receptor overexpression downregulate AT1a and TGF-beta receptors in VSMCs from spontaneously hypertensive rats compared to normotensive rats?
The failure of AT2 receptor overexpression to downregulate AT1a and TGF-beta receptors in VSMCs from spontaneously hypertensive rats may contribute to the exaggerated vascular smooth muscle cell growth seen in hypertension.
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AT2 effects on receptors are blunted in SHR VSMCs; hypothesis-generating for hypertension-specific mechanisms.
Su et al. (2002) studied Hypertension. AT2 receptor gene transfection vs. Untransfected cells / WKY vs SHR was evaluated on Expression of AT1a receptor and TGF-beta type I receptor, and DNA synthesis. Transfection of the AT2 receptor downregulated AT1a and TGF-beta type I receptors in normal VSMCs from WKY rats, but failed to downregulate these receptors in VSMCs from spontaneously hypertensive rats.
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